Kim Ki Hoon, Jo Jeong Hyun, Cho Hye Jin, Park Tae Sub, Kim Tae Min
Graduate School of International Agricultural Technology, Pyeongchang, South Korea.
2Institutes of Green-Bio Science and Technology, Seoul National University, Pyeongchang, Gangwon-do 25354 South Korea.
Lab Anim Res. 2020 Apr 15;36:10. doi: 10.1186/s42826-020-00043-3. eCollection 2020.
Extracellular vesicles (EVs) are nano-sized particles secreted by almost all cell types, and they mediate various biological processes via cell-to-cell communication. Compared with parental cells for therapeutic purposes, stem cell-derived EVs have several advantages such as reduced risk of rejection, less oncogenic potential, ease of long-term storage, lower chance of thromboembolism, and readiness for immediate use. Recent studies have demonstrated that EVs from stem cells, mostly from mesenchymal stem cells (MSCs) from various tissues, have anti-inflammatory, anti-oxidative, anti-apoptotic, and proliferative role in injured organs including osteoarthritic lesions. Herein, we provide a review about the up-to-date studies in preclinical application of stem cell-derived EVs in osteoarthritis animal arthritis models.
细胞外囊泡（EVs）是几乎所有细胞类型分泌的纳米级颗粒，它们通过细胞间通讯介导各种生物学过程。与用于治疗目的的亲代细胞相比，干细胞衍生的细胞外囊泡具有几个优点，例如降低排斥风险、致癌潜力较小、易于长期储存、血栓栓塞几率较低以及可立即使用。最近的研究表明，来自干细胞的细胞外囊泡，主要来自各种组织的间充质干细胞（MSCs），在包括骨关节炎病变在内的受损器官中具有抗炎、抗氧化、抗凋亡和增殖作用。在此，我们综述了干细胞衍生的细胞外囊泡在骨关节炎动物关节炎模型临床前应用的最新研究。
