Baker John G, Willer Barry S, Dwyer Michael G, Leddy John J
Departments of UBMD Orthopedics and Sports Medicine and Nuclear Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo , Buffalo, New York, USA.
Department of Psychiatry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo , Buffalo, New York, USA.
Brain Inj. 2020 May 11;34(6):818-827. doi: 10.1080/02699052.2020.1749932. Epub 2020 Apr 23.
To introduce the concept of cognitive intolerance. A test is proposed to measure this concept and pilot data are presented to support this measure and future research to develop this concept into a construct. : Three-group comparison to protect larger study blinding. : Two groups of student athletes (n = 13, n = 13) between 13 and 17 (mean 15.1 ± 1.1 years; 58% male) who sustained a sport-related concussion within 10 days and one group (n = 13) of age-matched healthy controls were recruited for a comparison of correlations between self and observer ratings of cognitive difficulties and DTI fractional anisotropy (FA) using tract-based spatial statistics (TBSS) analysis at two time points. : Significant negative only associations (higher cognitive difficulty and lower FA) with DTI FA were found in white matter tracts. These included the anterior corpus callosum, frontal-parietal longitudinal fasciculi, and cortical-subcortical pathways at only the second time point. Several working memory networks would likely involve connections using the above-identified white matter tracts. : Cognitive intolerance can be defined as symptom exacerbation from prolonged cognitive activity. Cognitive intolerance could be measured by the n-back working memory task and time to symptom exacerbation.
介绍认知不耐受的概念。提出了一项测试来衡量这一概念，并展示了试点数据以支持这一测量方法以及未来将这一概念发展为一种结构的研究。：进行三组比较以保护更大规模研究的盲法。：招募了两组13至17岁（平均15.1±1.1岁；58%为男性）的学生运动员（n = 13，n = 13），他们在10天内遭受了与运动相关的脑震荡，以及一组年龄匹配的健康对照组（n = 13），用于比较两个时间点使用基于体素的空间统计学（TBSS）分析的认知困难的自我评分与观察者评分以及弥散张量成像（DTI）分数各向异性（FA）之间的相关性。：在白质束中仅发现了与DTI FA的显著负相关（认知困难程度越高，FA越低）。这些白质束包括胼胝体前部、额顶叶纵向束以及仅在第二个时间点的皮质 - 皮质下通路。几个工作记忆网络可能涉及使用上述确定的白质束的连接。：认知不耐受可定义为长时间认知活动导致的症状加重。认知不耐受可以通过n-back工作记忆任务和症状加重时间来衡量。
