Niinikoski J, Vänttinen E
Department of Surgery, University of Turku, Finland.
Acta Chir Scand. 1988 Nov-Dec;154(11-12):641-5.
This work was undertaken to investigate the effects of intraarterially administered pentoxifylline (100 mg) and papaverine (40 mg) on transcutaneous oxygen tension, calf muscle oxygen tension and skin red cell flux in ischemic limbs of patients undergoing aortofemoral reconstruction due to obstructive arteriosclerosis. The drugs were injected intraoperatively, one at a time, into the common femoral artery of the most affected side before and/or after the insertion of the prosthesis in altogether 10 patients. Both drugs appeared to have an augmenting effect on transcutaneous and muscle tissue oxygen tensions. The maximal response of these variables was usually higher after papaverine injection, but the duration of the effect was longer after pentoxifylline administration. Skin red cell flux underwent an immediate, short-term increase after each papaverine injection, but remained unchanged after pentoxifylline administration.
本研究旨在探讨动脉内注射己酮可可碱（100毫克）和罂粟碱（40毫克）对因阻塞性动脉硬化而行主-股动脉重建术患者缺血肢体经皮氧分压、小腿肌肉氧分压及皮肤红细胞通量的影响。在总共10例患者中，于术中在植入假体之前和/或之后，将药物一次一种注射到最受影响侧的股总动脉中。两种药物似乎都对经皮和肌肉组织氧分压有增强作用。这些变量的最大反应通常在注射罂粟碱后更高，但己酮可可碱给药后的作用持续时间更长。每次注射罂粟碱后，皮肤红细胞通量立即出现短期增加，但己酮可可碱给药后保持不变。
