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生物测定导向分离（L.） Dumort. 的抗增殖化合物

Bioassay-Guided Isolation of Antiproliferative Compounds from (L.) Dumort.

机构信息

Department of Medicine, Foligno Nursing School, University of Perugia, 06034 Foligno, Italy.

Department of Biomolecular Sciences, Section of Biochemistry and Biotechnology, University of Urbino, 61029 Urbino, Italy.

出版信息

Molecules. 2020 Apr 20;25(8):1893. doi: 10.3390/molecules25081893.

DOI:10.3390/molecules25081893
PMID:32325960
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7221903/
Abstract

(L.) Dumort (Asteraceae) -hexane extract displayed high cell proliferation inhibitory activity against acute myeloid leukaemia cells (OCI-AML3) and was therefore subjected to a bioassay-guided multistep separation procedure. Two thymol derivatives, namely 10-acetoxy-8,9-epoxythymol tiglate () and 10-acetoxy-9-chloro-8,9-dehydrothymol (), were isolated and identified by means of NMR spectroscopy. Both of them exhibited a significant dose-dependent inhibition of cell proliferation.

摘要

(L.) 土木香（菊科）-己烷提取物对急性髓性白血病细胞（OCI-AML3）表现出高细胞增殖抑制活性，因此进行了基于生物测定的多步分离程序。分离得到两种百里酚衍生物，即 10-乙酰氧基-8,9-环氧百里酚异戊烯酸酯（）和 10-乙酰氧基-9-氯-8,9-脱氢百里酚（），并通过 NMR 光谱鉴定。两者均表现出显著的剂量依赖性细胞增殖抑制作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bbf/7221903/fec8ee59647a/molecules-25-01893-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bbf/7221903/c2095d8b0856/molecules-25-01893-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bbf/7221903/4c89c5bc42d9/molecules-25-01893-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bbf/7221903/70160b8681b7/molecules-25-01893-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bbf/7221903/fa730e9ebf53/molecules-25-01893-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bbf/7221903/47c2d291099a/molecules-25-01893-g005a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bbf/7221903/fec8ee59647a/molecules-25-01893-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bbf/7221903/c2095d8b0856/molecules-25-01893-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bbf/7221903/4c89c5bc42d9/molecules-25-01893-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bbf/7221903/70160b8681b7/molecules-25-01893-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bbf/7221903/fa730e9ebf53/molecules-25-01893-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bbf/7221903/47c2d291099a/molecules-25-01893-g005a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bbf/7221903/fec8ee59647a/molecules-25-01893-g006.jpg

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