Department of Radiology and Nuclear Medicine, Otto-von-Guericke University Magdeburg, Germany.
Institute of Medical Epidemiology, Biostatistics, and Informatics, Martin-Luther-University Halle-Wittenberg, Germany.
Acad Radiol. 2021 Apr;28(4):e110-e117. doi: 10.1016/j.acra.2020.02.030. Epub 2020 Apr 21.
To date, there are inconsistent data about relationships between 2-deoxy-2 [F] fluoro-D-glucose positron emission tomography (FDG-PET) and expression of vascular endothelial growth factor (VEGF) and microvessel density (MVD). The aim of the present meta-analysis was to systematize the reported data about associations between maximal standardized uptake value (SUV) derived from FDG PET and expression of VEGF and as well as MVD.
MEDLINE library, SCOPUS and EMBASE data bases were screened for relationships between SUV and VEGF/MVD up to October 2019. Overall, in 18 studies correlations between SUV and VEGF and in 13 studies correlations between SUV and MVD were reported. The following data were extracted from the literature: authors, year of publication, number of patients, and correlation coefficients.
Associations between 18F-FDG PET and VEGF were reported in 18 studies (935 patients). The calculated correlation coefficients between SUVmax and VEGF expression ranged from -0.16 to 0.88. The pooled correlation coefficient was 0.32, (95% confidence interval [CI] = [0.15; 0.48]). Associations between 18F-FDG PET and MVD were investigated in 13 studies (593 patients). The reported correlation coefficients ranged from -0.23 to 0.91. The pooled correlation coefficient was 0.27, (95% CI = [0.00; 0.53]). Analysis of MVD based on CD105 immunohistochemical staining was performed in four studies (117 patients). The pooled correlation coefficient was 0.41 (95% CI = [0.22; 0.59]). In three reports with 233 patients, MVD was estimated by staining with CD31 antibody. The pooled correlation coefficient was 0.01, (95% CI = [-0.44; 0.47]). Finally, in 9 studies (280 patients) MVD was performed on CD34 stained specimens. The pooled correlation coefficient was 0.36, (95% CI = [0.09; 0.63]).
SUV of FDG PET correlated weakly with expression of VEGF and with MVD. Therefore, FDG PET cannot predict neoangiogenesis in malignant tumors.
迄今为止，关于 2-脱氧-2-[F]氟代-D-葡萄糖正电子发射断层扫描（FDG-PET）与血管内皮生长因子（VEGF）表达和微血管密度（MVD）之间的关系，数据不一致。本荟萃分析的目的是系统地总结报告的关于 FDG PET 衍生的最大标准化摄取值（SUV）与 VEGF 和 MVD 表达之间的关联的数据。
筛选了 MEDLINE 图书馆、SCOPUS 和 EMBASE 数据库，以获取截至 2019 年 10 月的 FDG PET 与 VEGF/MVD 之间关系的报告。总的来说，18 项研究报告了 SUV 与 VEGF 之间的相关性，13 项研究报告了 SUV 与 MVD 之间的相关性。从文献中提取了以下数据：作者、出版年份、患者数量和相关系数。
18F-FDG PET 与 VEGF 的相关性在 18 项研究（935 例患者）中报道。SUVmax 与 VEGF 表达之间的计算相关系数范围为-0.16 至 0.88。汇总相关系数为 0.32（95%置信区间[CI]：[0.15；0.48]）。13 项研究调查了 18F-FDG PET 与 MVD 的相关性（593 例患者）。报告的相关系数范围为-0.23 至 0.91。汇总相关系数为 0.27（95%CI：[0.00；0.53]）。4 项研究（117 例患者）基于 CD105 免疫组织化学染色分析了 MVD。汇总相关系数为 0.41（95%CI：[0.22；0.59]）。在 3 项包含 233 例患者的报告中，通过 CD31 抗体染色估计了 MVD。汇总相关系数为 0.01（95%CI：[-0.44；0.47]）。最后，在 9 项研究（280 例患者）中，使用 CD34 染色标本进行了 MVD。汇总相关系数为 0.36（95%CI：[0.09；0.63]）。
FDG PET 的 SUV 与 VEGF 表达和 MVD 弱相关。因此，FDG PET 不能预测恶性肿瘤的新生血管形成。
