Department of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig, Germany.
Department of Diagnostic and Interventional Radiology, University of Ulm, Ulm, Germany.
Acta Radiol. 2021 Apr;62(4):557-564. doi: 10.1177/0284185120932378. Epub 2020 Jun 19.
Hypoxia-inducible factor (HIF)-1α plays a key role in hypoxic adaptation of tumor cells. Overexpression of HIF-1α is associated with tumor aggressiveness and worse prognosis in several malignancies. Presumably, expression of HIF-1a may be reflected by positron emission tomography with 2-deoxy-2 [fluorine-18] fluoro-D-glucose (18F-FDG PET). There are inconsistent data about relationships between FDG PET and HIF-1α.
To provide evident data about associations between maximum standardized uptake value (SUV) and HIF-1α expression in solid tumors.
MEDLINE, SCOPUS, and EMBASE databases were screened for relationships between SUV and HIF-1α up to August 2019. Overall, 21 studies with 1154 patients were identified. The following data were extracted from the literature: authors; year of publication; number of patients; and correlation coefficients.
Correlation coefficients between SUV and HIF-1α were in the range of -0.51-0.71. The pooled correlation coefficient was 0.27 (95% confidence interval [CI] = 0.14-0.41). Furthermore, correlation coefficients for some tumor entities were calculated. For this sub-analysis, data for primary tumors with >2 reports were included. The calculated correlation coefficients in the analyzed subgroups were as follows: head and neck squamous cell carcinoma: ρ = 0.25 (95% CI = 0.07-0.42); non-small lung cell cancer: ρ = 0.27 (95% CI = -0.14-0.67); uterine cervical cancer: ρ = -0.09 (95% CI = -0.89-0.71); thymic tumors: ρ = 0.39 (95% CI = 0.04-0.58).
SUV of FDG PET correlated weakly with expression of HIF-1α both in overall sample and tumor subgroups. Therefore, FDG PET cannot be used for prediction of hypoxia in clinical practice.
缺氧诱导因子（HIF）-1α 在肿瘤细胞的缺氧适应中起关键作用。HIF-1α 的过度表达与几种恶性肿瘤的侵袭性和预后较差有关。推测 HIF-1a 的表达可以通过正电子发射断层扫描与 2-脱氧-2-[氟-18]氟-D-葡萄糖（18F-FDG PET）来反映。关于 FDG PET 与 HIF-1α 之间的关系，存在不一致的数据。
提供关于实体瘤中最大标准化摄取值（SUV）与 HIF-1α 表达之间关系的明确数据。
截至 2019 年 8 月，在 MEDLINE、SCOPUS 和 EMBASE 数据库中筛选了 SUV 与 HIF-1α 之间关系的文献。共确定了 21 项研究，涉及 1154 名患者。从文献中提取以下数据：作者、发表年份、患者数量和相关系数。
SUV 与 HIF-1α 之间的相关系数在-0.51 至 0.71 之间。汇总的相关系数为 0.27（95%置信区间[CI] = 0.14-0.41）。此外，还计算了一些肿瘤实体的相关系数。对于这个亚分析，只包括了有>2 个报告的原发肿瘤的数据。在分析的亚组中计算出的相关系数如下：头颈部鳞状细胞癌：ρ=0.25（95%CI=0.07-0.42）；非小细胞肺癌：ρ=0.27（95%CI=-0.14-0.67）；子宫颈癌：ρ=-0.09（95%CI=-0.89-0.71）；胸腺瘤：ρ=0.39（95%CI=0.04-0.58）。
FDG PET 的 SUV 与总体样本和肿瘤亚组中的 HIF-1α 表达均呈弱相关。因此，FDG PET 不能用于预测临床实践中的缺氧。
