College of Animal Science and Technology, Guangxi University, Nanning, China.
Front Endocrinol (Lausanne). 2020 Apr 9;11:194. doi: 10.3389/fendo.2020.00194. eCollection 2020.
RF amide-related peptide 3 (RFRP-3) is a reproductive inhibitor and an endogenous orexigenic neuropeptide that may be involved in energy homeostasis. In this study, we evaluated the effect of acute or chronic RFRP-3 treatment (administered via intraperitoneal injection) on the food intake, meal microstructure and weight of rats, as well as the mechanism through which RFRP-3 is involved in glucose metabolism in the pancreas and glucose disposal tissues of rat . Our results showed that the intraperitoneal administration of RFRP-3 to rats resulted in marked body mass increased, hyperphagia, hyperlipidemia, hyperglycemia, glucose intolerance, hypoinsulinism, hyperglucagon, and insulin resistance, as well as significant increases in the size of pancreatic islets and the inflammatory reaction. Thus, we strongly assert that RFRP-3 as a novel neuroendocrine regulator involved in blood glucose homeostasis.
促性腺激素释放激素酰胺相关肽 3（RFRP-3）是一种生殖抑制剂和内源性食欲肽，可能参与能量平衡。在这项研究中，我们评估了急性或慢性 RFRP-3 治疗（通过腹腔注射给予）对大鼠摄食量、餐食结构和体重的影响，以及 RFRP-3 参与大鼠胰腺葡萄糖代谢和葡萄糖处置组织的机制。我们的结果表明，腹腔内给予 RFRP-3 会导致大鼠体重明显增加、暴食、高血脂、高血糖、葡萄糖耐量降低、胰岛素分泌不足、高胰高血糖素和胰岛素抵抗，以及胰岛和炎症反应的显著增大。因此，我们强烈断言 RFRP-3 作为一种新的参与血糖稳态的神经内分泌调节剂。
