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急性肠系膜缺血治疗过程中遇到的挑战。

Challenges Encountered during the Treatment of Acute Mesenteric Ischemia.

作者信息

Jagielski Mateusz, Piątkowski Jacek, Jackowski Marek

机构信息

Department of General, Gastroenterological and Oncological Surgery, Collegium Medicum Nicolaus Copernicus University, Toruń, Poland.

出版信息

Gastroenterol Res Pract. 2020 Mar 31;2020:5316849. doi: 10.1155/2020/5316849. eCollection 2020.

Abstract

RESULTS

Acute ischemia of the bowel mesentery was diagnosed in 41 patients (27 women and 14 men; mean age, 65.4 years). All patients underwent laparotomy. For 13 (31.71%) patients, surgery was performed within the first 24 hours of the clinical symptom onset. Mesenteric artery embolectomy without intestine resection was performed for 7 (17.07%) patients. Partial intestine resection due to necrosis was performed for 21 (51.22%) patients. Exploratory laparotomy without a therapeutic procedure was performed for 13 (31.71%) patients. Fifteen (36.59%) patients were discharged home in good general condition. Twenty-six (63.41%) patients died. The time from the clinical symptom onset until intervention exceeded 24 hours for all patients who died. Surgery within the first 24 hours reduced mortality associated with acute mesenteric ischemia ( = 0.001). Female sex, age older than 65 years, obesity (body mass index > 30), diabetes, chronic kidney disease, and smoking were adverse prognostic factors for increased mortality for patients with acute bowel ischemia.

CONCLUSION

The time from clinical symptoms to acute mesenteric ischemia treatment was the main prognostic factor and helped determine appropriate management. Early diagnosis and rapid intervention improved treatment outcomes and survival.

摘要

结果

41例患者(27例女性,14例男性;平均年龄65.4岁)被诊断为肠系膜急性缺血。所有患者均接受了剖腹手术。13例(31.71%)患者在临床症状出现后的24小时内接受了手术。7例(17.07%)患者接受了肠系膜动脉栓子切除术且未进行肠切除。21例(51.22%)患者因肠坏死接受了部分肠切除术。13例(31.71%)患者接受了未进行治疗性操作的剖腹探查术。15例(36.59%)患者出院时一般情况良好。26例(63.41%)患者死亡。所有死亡患者从临床症状出现到干预的时间均超过24小时。在最初24小时内进行手术可降低与急性肠系膜缺血相关的死亡率(P = 0.001)。女性、年龄大于65岁、肥胖(体重指数>30)、糖尿病、慢性肾病和吸烟是急性肠缺血患者死亡率增加的不良预后因素。

结论

从临床症状出现到急性肠系膜缺血治疗的时间是主要的预后因素,有助于确定合适的治疗方案。早期诊断和快速干预可改善治疗效果和生存率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2285/7150694/123d5eb7b7a5/GRP2020-5316849.sch.001.jpg

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