Zhang Zeng-Liang, Li Li-Jie, Sun Dan, Wang Min, Shi Ju-Ran, Yang Di, Wang Lu-Hui, Zou Sheng-Can
R&D Center Yihai Industry Holding Co., Ltd. Qingdao China.
Food Sci Nutr. 2020 Feb 28;8(4):1933-1941. doi: 10.1002/fsn3.1479. eCollection 2020 Apr.
In this study, the chitosan-based release microspheres were prepared by spray drying method. Chitosan was used as the carrier material, and extract, extract, and extract (the mass ratio was 2:7:5) were active substance. The spray drying preparation process of microsphere was optimized by single factor experiment and L (3) orthogonal design. Drug loading (DL), particle size, and sustained release performance of microspheres were investigated. The mass fraction of chitosan was 1.5%, the mass ratio of drug to chitosan was 1:3, the inlet air temperature was 130°C, and the injection rate was 400 ml/hr. The chitosan-based microspheres prepared under the above conditions had a smooth surface, and the DL was 23.87 ± 0.93%; the average particle diameter was 10.27 ± 1.05 μm, and the encapsulation efficiency (EE) of the microspheres was 91.28 ± 1.04%. The preparation process of chitosan-based drug microsphere prepared by spray drying method was simple and stable. The prepared microspheres in this paper showed a sustained release effect in vitro.
本研究采用喷雾干燥法制备了壳聚糖基缓释微球。以壳聚糖为载体材料，提取物、提取物和提取物（质量比为2:7:5）为活性物质。通过单因素实验和L(3)正交设计对微球的喷雾干燥制备工艺进行了优化。考察了微球的载药量（DL）、粒径和缓释性能。壳聚糖的质量分数为1.5%，药物与壳聚糖的质量比为1:3，进风温度为130℃，注射速率为400 ml/hr。在上述条件下制备的壳聚糖基微球表面光滑，载药量为23.87±0.93%；平均粒径为10.27±1.05μm，微球的包封率（EE）为91.28±1.04%。喷雾干燥法制备壳聚糖基药物微球的工艺简单、稳定。本文制备的微球在体外具有缓释效果。
