Tang Dale D, Liao Guoning, Gerlach Brennan D
Department of Molecular and Cellular Physiology, Albany Medical College, 47 New Scotland Avenue, MC-8, Albany, NY 12118 e-mail:
Department of Molecular and Cellular Physiology, Albany Medical College, 47 New Scotland Avenue, MC-8, Albany, NY 12118.
J Eng Sci Med Diagn Ther. 2019 Feb;2(1):0108011-108015. doi: 10.1115/1.4042313. Epub 2019 Jan 18.
Vimentin intermediate filaments (IFs) link to desmosomes (intercellular junctions) on the membrane and dense bodies in the cytoplasm, which provides a structural base for intercellular and intracellular force transmission in smooth muscle. There is evidence to suggest that the vimentin framework plays an important role in mediating smooth muscle mechanical properties such as tension and contractile responses. Contractile activation induces vimentin phosphorylation at Ser-56 and vimentin network reorientation, facilitating contractile force transmission among and within smooth muscle cells. p21-activated kinase 1 and polo-like kinase 1 catalyze vimentin phosphorylation at Ser-56, whereas type 1 protein phosphatase dephosphorylates vimentin at this residue. Vimentin filaments are also involved in other cell functions including migration and nuclear positioning. This review recapitulates our current knowledge how the vimentin network modulates mechanical and biological properties of smooth muscle.
波形蛋白中间丝（IFs）与细胞膜上的桥粒（细胞间连接）和细胞质中的致密体相连，这为平滑肌中的细胞间和细胞内力传递提供了结构基础。有证据表明，波形蛋白框架在介导平滑肌的机械特性（如张力和收缩反应）中起重要作用。收缩激活诱导波形蛋白在Ser-56处磷酸化以及波形蛋白网络重新定向，促进平滑肌细胞之间和内部的收缩力传递。p21激活激酶1和polo样激酶1催化波形蛋白在Ser-56处磷酸化，而1型蛋白磷酸酶使该残基处的波形蛋白去磷酸化。波形蛋白丝还参与其他细胞功能，包括迁移和核定位。本综述概述了我们目前关于波形蛋白网络如何调节平滑肌的机械和生物学特性的知识。
