加入 SNX：SNX9 驱动丝状伪足的发生。

Adding SNX to the mix: SNX9 drives filopodia biogenesis.

机构信息

Department of Molecular & Cell Biology and Institute for Systems Genomics, University of Connecticut, Storrs, CT.

出版信息

J Cell Biol. 2020 Apr 6;219(4). doi: 10.1083/jcb.202002086.

DOI:10.1083/jcb.202002086

PMID:32328644

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7147100/

Abstract

Filopodia are actin-rich protrusions important for sensing and responding to the extracellular environment, but the repertoire of factors required for filopodia formation is only partially understood. Jarsch et al. (2020. J. Cell. Biol. https://doi.org/10.1083/jcb.201909178) combine an in vitro system of filopodia biogenesis with a phage display screen to show that SNX9 drives filopodial assembly.

摘要

丝状伪足是富含肌动蛋白的突起，对于感知和响应细胞外环境很重要，但对于形成丝状伪足所需的因子谱仅部分了解。Jarsch 等人（2020.《细胞生物学杂志》。https://doi.org/10.1083/jcb.201909178）结合丝状伪足生物发生的体外系统和噬菌体展示筛选，表明 SNX9 驱动丝状伪足的组装。