Institute of Human Genetics, Polish Academy of Science, Strzeszynska 32, 60-479, Poznan, Poland.
J Appl Genet. 2020 Sep;61(3):415-419. doi: 10.1007/s13353-020-00558-4. Epub 2020 Apr 24.
RNA helicases are known from their ability to bind and unwind double-stranded RNA initiating RNA processing events. These evolutionary conserved RNA binding proteins are broadly expressed in a variety of tissues; however, we can distinguish those, which represent tissue-specific expression pattern and play unique roles in certain cell lineages. For instance, some RNA helicases mediate transcriptomic changes triggering cell differentiation which results in specification and establishment of germline in a developing embryo. Others act as safeguards responsible for maintenance of DNA integrity in germ cell. In this article, we focus on selected DEAD/DEAH-box RNA helicases involved in germline development and spermatogenesis presenting their diverse functions and implications for male fertility.
RNA 解旋酶以结合和解开双链 RNA 从而启动 RNA 加工事件的能力而闻名。这些进化上保守的 RNA 结合蛋白在各种组织中广泛表达；然而，我们可以区分那些代表组织特异性表达模式并在某些细胞谱系中发挥独特作用的 RNA 解旋酶。例如，一些 RNA 解旋酶介导转录组变化，触发细胞分化，从而导致发育中的胚胎中的生殖细胞的特化和建立。其他 RNA 解旋酶则作为负责维持生殖细胞中 DNA 完整性的保护者。在本文中，我们重点介绍参与生殖细胞发育和精子发生的选定的 DEAD/DEAH 盒 RNA 解旋酶，展示它们的多种功能及其对男性生育能力的影响。
