Department of Medical Biochemistry and Microbiology, Voronezh State University, Voronezh, Russia.
Department of Human and Animal Physiology, Medical and Biological Faculty, Voronezh State University, Voronezh, Russia.
Bull Exp Biol Med. 2020 Apr;168(6):761-766. doi: 10.1007/s10517-020-04797-7. Epub 2020 Apr 23.
We studied activities of antioxidant system enzymes in tissues of rats with experimental allergic encephalomyelitis. It was shown that the development of pathology is accompanied by deformation of the neurons and axonal degeneration, intensification of free radical oxidation, exhaustion of the reduced glutathione pool, and multidirectional changes in activities of antioxidant enzymes in rat tissues. The observed imbalance in the antioxidant defense system can be associated with excessive glutathione utilization in the glutathione transferase reaction and different severity of the pathological process in the brain and spinal cord. The received data necessitate the search for compounds that can prevent inhibition of antioxidant system components in order to analyze the possibility of their use in the treatment of multiple sclerosis.
我们研究了实验性变态反应性脑脊髓炎大鼠组织中抗氧化系统酶的活性。结果表明，病理发生伴随着神经元变形和轴突退化、自由基氧化加剧、还原型谷胱甘肽池耗竭以及大鼠组织中抗氧化酶活性的多向变化。观察到的抗氧化防御系统失衡可能与谷胱甘肽转移酶反应中谷胱甘肽的过度利用以及大脑和脊髓中病理过程的严重程度不同有关。所获得的数据需要寻找可以防止抗氧化系统成分抑制的化合物，以分析它们在多发性硬化症治疗中的使用可能性。
