Kryl'skii E D, Razuvaev G A, Potapova T N, Akinina A I, Nihaev L E
Department of Medical Biochemistry and Microbiology, Voronezh State University, Voronezh, Russia.
Bull Exp Biol Med. 2021 Oct;171(6):716-721. doi: 10.1007/s10517-021-05302-4. Epub 2021 Oct 27.
A comprehensive study of the functioning of antioxidant system in rats with rotenone-induced parkinsonism was conducted. The development of pathology led to inhibition of the majority of the studied antioxidant enzymes in the brain and blood serum of animals, which can be associated with decompensation of oxidative stress under conditions of prolonged mitochondrial dysfunction. These changes apparently make an important contribution into neuronal degeneration in the cerebral cortex and striatum and motor disorders in experimental animals.
对鱼藤酮诱导的帕金森病大鼠抗氧化系统的功能进行了全面研究。病理学的发展导致动物大脑和血清中大多数被研究的抗氧化酶受到抑制，这可能与长期线粒体功能障碍条件下氧化应激的失代偿有关。这些变化显然对实验动物大脑皮质和纹状体中的神经元变性以及运动障碍有重要影响。
