Interdisciplinary Program of Bioenergy and Biomaterials, Graduate School, College of Engineering, College of Engineering, Chonnam National University, Gwangju 61186, Republic of Korea.
Division of Functional Food Research, Korea Food Research Institute, Wanju 55365, Republic of Korea.
Am J Chin Med. 2020;48(3):615-629. doi: 10.1142/S0192415X20500317. Epub 2020 Apr 24.
Mitochondrial metabolism plays a crucial role in insulin resistance and insulin secretion in type 2 diabetes mellitus (T2D). Some studies have focused on how extracts affect insulin resistance and hyperglycemia. However, the effects of extracts on mitochondrial dysfunction associated with insulin secretion have not been well explained. In this study, well-known effective compounds extracted from using 70% ethanol were administered to a high-fat diet (HFD) fed mouse to examine the effects of ethanolic extracts (CSEE) on mitochondrial dysfunction in the pancreas. Furthermore, we examined how CSEE regulates the basal mechanism of insulin secretion through mitochondrial functions. Our experimental data suggest that pancreatic mitochondrial metabolism in HFD mice is enhanced to compensate for constrained glucose consumption. HFD-fed mice treated with CSEE showed improved pancreatic mitochondrial functions resulting in alleviation of insulin resistance at target tissue as well as basal hyperinsulinemia.
线粒体代谢在 2 型糖尿病（T2D）的胰岛素抵抗和胰岛素分泌中起着至关重要的作用。一些研究集中在 提取物如何影响胰岛素抵抗和高血糖。然而， 提取物对与胰岛素分泌相关的线粒体功能障碍的影响尚未得到很好的解释。在这项研究中，使用 70%乙醇从 中提取的众所周知的有效化合物被给予高脂肪饮食（HFD）喂养的小鼠，以检查 乙醇提取物（CSEE）对胰腺中线粒体功能障碍的影响。此外，我们研究了 CSEE 如何通过线粒体功能调节胰岛素分泌的基础机制。我们的实验数据表明，HFD 小鼠的胰腺线粒体代谢增强，以补偿受限的葡萄糖消耗。用 CSEE 治疗的 HFD 喂养的小鼠表现出改善的胰腺线粒体功能，导致靶组织的胰岛素抵抗以及基础高胰岛素血症得到缓解。
