Cocke T B, Fisch S, Gilmore H R, Okun R, Tamagna I G, Wipplinger K
J Clin Pharmacol. 1977 May-Jun;17(5-6):334-8. doi: 10.1002/j.1552-4604.1977.tb04613.x.
The results from this double-blind, multi-investigator study showed that a combination of 50 mg triamterene plus 25 mg hydrochlorothiazide and a combination of 25 mg spironolactone plus 25 mg hydrochlorothiazide were equally efficacious in lowering blood pressure in hypertensive outpatients, and that they produced the same type and incidence of adverse effects. Likewise, the two drug combinations produced similar effects on blood chemistry and hematology. There were no significant differences between the two combination drugs in efficacy laboratory studies, or adverse effects.
这项双盲、多研究者参与的研究结果表明，50毫克氨苯蝶啶加25毫克氢氯噻嗪的组合与25毫克螺内酯加25毫克氢氯噻嗪的组合在降低高血压门诊患者血压方面同样有效，且产生的不良反应类型和发生率相同。同样，这两种药物组合对血液化学和血液学产生了相似的影响。在疗效实验室研究或不良反应方面，这两种组合药物之间没有显著差异。
