Kohvakka A, Eisalo A, Manninen V
Acta Med Scand. 1979;205(4):319-24. doi: 10.1111/j.0954-6820.1979.tb06056.x.
The relative efficacies of potassium chloride, amiloride, triamterene and spironolactone in maintaining potassium balance were studied in 40 patients with essential hypertension receiving diuretic therapy. The preparations were administered in random order in a cross-over manner. In 31 patients treated with 50 mg hydrochlorothiazide daily, addition of 1500 mg potassium chloride daily was the weakest and 50 mg spironolactone daily the most effective agent for maintaining serum potassium. Amiloride (5 mg daily) and triamterene (75 mg daily) were less effective and equally so. Similar results were obtained with 9 patients treated with double dosages of the diuretic and supplements. Despite changes in serum potassium, total body potassium remained constant throughout the trial.
在40例接受利尿治疗的原发性高血压患者中，研究了氯化钾、氨苯蝶啶、氨氯吡咪和安体舒通在维持钾平衡方面的相对疗效。这些制剂以交叉方式随机给药。在31例每日服用50毫克氢氯噻嗪的患者中，每日添加1500毫克氯化钾是维持血清钾最无效的药物，而每日50毫克安体舒通则是最有效的药物。氨苯蝶啶（每日5毫克）和氨氯吡咪（每日75毫克）效果较差且相当。在9例接受双倍剂量利尿剂和补充剂治疗的患者中也得到了类似结果。尽管血清钾发生了变化，但在整个试验过程中总体钾含量保持恒定。
