Lechin F, Van Der Dijs B, Bentolila A, Peña F
J Clin Pharmacol. 1977 May-Jun;17(5-6):339-49. doi: 10.1002/j.1552-4604.1977.tb04614.x.
Dihydroergotamine (DHE), an alpha-adrenergic blocking agent, rapidly improved 121 out of 123 diarrheal patients. A hypotonic sigmoid and a hyperreactive rectum were found in these patients. Manometric studies of the distal colon showed that DHE counteracts the rectal hyperactivity and increases sigmoidal tone. On the other hand, anticholinergic drugs and/or emotional stimuli accentuate the rectal hyperactivity of diarrheal patients. Both features could be due to an unbalanced neurologic control of the gastrointestinal tract with dominance of the alpha-adrenergic over the cholinergic activity. Diphenoxylate (DPO) suppressed the diarrhea in two patients not improved by DHE. Furthermore, DPO reinforced the therapeutic success of DHE in 11 lactose intolerance diarrheal patients, suggesting that the two drugs exert their effects by means of different mechanisms.
双氢麦角胺（DHE），一种α-肾上腺素能阻滞剂，使123例腹泻患者中的121例迅速好转。在这些患者中发现乙状结肠低张和直肠反应性亢进。对远端结肠的测压研究表明，DHE可抵消直肠的过度活动并增加乙状结肠张力。另一方面，抗胆碱能药物和/或情绪刺激会加剧腹泻患者的直肠过度活动。这两种特征可能是由于胃肠道神经控制失衡，α-肾上腺素能活性优于胆碱能活性所致。地芬诺酯（DPO）使2例未被DHE改善的患者腹泻得到缓解。此外，DPO增强了DHE对11例乳糖不耐受性腹泻患者的治疗效果，提示这两种药物通过不同机制发挥作用。
