Lechin F, Van Der Dijs B
J Clin Pharmacol. 1979 Oct;19(10):617-25. doi: 10.1002/j.1552-4604.1979.tb01624.x.
Four different dopaminergic blocking agents were able to modify the motility of the distal colon: haloperidol, sulpiride, pimozide, and thioridazine. Haloperidol and sulpiride induced different and frequently antagonistic responses; however, the effects induced by these drugs changed depending on the preexisting pattern of motility. Intestinal tone and sigmoidal or rectal phasic activity predominance are the main factors that influence responses. Biperiden, a centrally acting anticholinergic drug, and dihydroergotamine, an antinoradrenergic drug, annulled the rebound of motility induced by sulpiride in high intestinal-tone and low intestinal-tone subjects, respectively. Our results suggest that the dopaminergic system plays a role in the distal colon motility in humans.
氟哌啶醇、舒必利、匹莫齐特和硫利达嗪。氟哌啶醇和舒必利引起不同且常常相互拮抗的反应；然而，这些药物所诱导的效应会根据预先存在的运动模式而改变。肠张力以及乙状结肠或直肠的相性活动优势是影响反应的主要因素。中枢性抗胆碱能药物苯海索和抗去甲肾上腺素能药物双氢麦角胺，分别消除了高肠张力和低肠张力受试者中舒必利所诱导的运动反跳。我们的结果表明，多巴胺能系统在人类结肠远端运动中发挥作用。
