Department of Microbiology, University College of Medical Sciences (University of Delhi), Guru Teg Bahadur Hospital, Delhi, India.
Department of Microbiology, University College of Medical Sciences (University of Delhi), Guru Teg Bahadur Hospital, Delhi, India; Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan, Saudi Arabia.
Biomed J. 2021 Aug;44(4):471-478. doi: 10.1016/j.bj.2020.03.011. Epub 2020 Apr 21.
Worldwide around 2 million deaths occur every year due to diarrhoeal illnesses among children less than 5 years of age. Among diarrhoeagenic Escherichia coli, Enteropathogenic E. coli (EPEC) is highly prevalent in both community and hospital settings and is one of the main causes of persistent diarrhea in children in developing countries. EPEC remains underdiagnosed in India due to lack of conventional tools for identification.
We in this study investigated the prevalence and regional variation of EPEC in paediatric population suffering from diarrhoea in East Delhi, India. Two hundred stool samples were collected from children, aged between 0.5 and 5 years, with acute diarrhoea. E. coli were identified by conventional tests and PCR.
We observed 7% atypical EPEC (aEPEC) and 2.5% typical EPEC (tEPEC), with an overall 9.5% EPEC prevalence amongst total samples. E. coli phylogenetic group A was the predominant. The most common age group affected was 6-23 months with common symptoms being vomiting, watery diarrhoea and severe dehydration. High drug resistance pattern was observed in EPEC isolates.
The study depicts a changing trend of aEPEC over tEPEC in children less than 5 years with diarrhoea, an emerging drug resistant enteropathogen and a public health concern demanding monitoring and surveillance.
全世界每年有 200 万人因 5 岁以下儿童的腹泻病而死亡。在致腹泻性大肠杆菌中，肠致病性大肠杆菌（EPEC）在社区和医院环境中都非常普遍，是发展中国家儿童持续性腹泻的主要原因之一。由于缺乏常规的鉴定工具，EPEC 在印度的诊断率仍然较低。
本研究调查了印度东德里患有腹泻的儿科人群中 EPEC 的流行情况和地区差异。从 0.5 至 5 岁的急性腹泻儿童中采集了 200 份粪便样本。通过常规试验和 PCR 鉴定大肠杆菌。
我们观察到 7%的非典型性 EPEC（aEPEC）和 2.5%的典型性 EPEC（tEPEC），总样本中 EPEC 的总体流行率为 9.5%。大肠杆菌的进化群 A 是主要的。受影响最常见的年龄组是 6-23 个月，常见症状是呕吐、水样腹泻和严重脱水。EPEC 分离株表现出高度耐药模式。
本研究描述了 5 岁以下腹泻儿童中 aEPEC 取代 tEPEC 的变化趋势，这是一种新兴的耐药性肠病原体，需要进行监测和监测，以引起公共卫生关注。
