[Use of tricyclic antidepressants in patients with chronic ischemic heart disease].

The results of a course of therapy in 187 men with proved ischemic heart disease (IHD) showed that tricyclic antidepressants in minimal and small doses may be effectively used in patients with IHD for treatment of psychic alterations as well as in chest pain syndrome. Amitriptyline was more effective than azafen or melipramine but significantly more often induced side effects. The data obtained demonstrated close relationship between the severity of psychic alterations and various clinical manifestations of angina pectoris as well as dependence of reduction of the anginal attacks frequency on the efficacy of psychic alterations therapy.