Loesche W J, Bradbury D R, Woolfolk M P
J Dent Res. 1977 Mar;56(3):254-65. doi: 10.1177/00220345770560031101.
A week of kanamycin gel treatment before and after the placement of dental restorations, compared to a placebo gel treatment, significantly reduced the levels of cultivable bacteria, S mutans and S sanguis, in the plaque samples collected immediately after the completion of the gel treatments, and was associated with a 46% reduction in new carious surfaces in the 14- to 37-month period following the gel treatment.
与安慰剂凝胶治疗相比，在放置牙齿修复体前后进行一周的卡那霉素凝胶治疗，显著降低了凝胶治疗完成后立即采集的菌斑样本中可培养细菌、变形链球菌和血链球菌的水平，并且与凝胶治疗后14至37个月期间新龋面减少46%相关。
