鼻腔盐水冲洗在儿童和成人变应性鼻炎治疗中的作用：系统分析。
Role of nasal saline irrigation in the treatment of allergic rhinitis in children and adults: A systematic analysis.
机构信息
Department of Otolaryngology, Tongji Hospital, Medical College of Tongji University, Shanghai 200065, China.
Department of Otolaryngology, Tongji Hospital, Medical College of Tongji University, Shanghai 200065, China.
出版信息
Allergol Immunopathol (Madr). 2020 Jul-Aug;48(4):360-367. doi: 10.1016/j.aller.2020.01.002. Epub 2020 Apr 21.
BACKGROUND
This meta-analysis aims to access the efficacy of nasal saline irrigation in the treatment of allergic rhinitis (AR) in adults and children.
METHODS
Two authors independently searched databases up to December 2018. Differences in efficacy between saline irrigation and other treatments were compared. Subgroup analyses of discrepancy in effects between children and adults were performed.
RESULTS
(1) Saline irrigation vs. no irrigation, in both children and adults groups, saline irrigation showed significant efficacy. (2) Saline+medication vs. medication, in children group, there was no statistical difference of efficacy between saline+medication and medication; in adults group, efficacy of saline+medicine was superior to that of medication. (3) Saline irrigation vs. medication, in children group, there was no statistical difference between efficacy of saline irrigation and medication; in adults group, efficacy of medication was superior to that of saline irrigation. (4) Hypertonic saline vs. isotonic saline, for children, efficacy of hypertonic saline was superior to that of isotonic saline. Additionally, no adults reported adverse events in all trials. Adverse effects were reported during the first nasal irrigation in 20 children, and one child withdrew due to adverse reactions.
CONCLUSIONS
Saline irrigation can significantly improve symptoms of AR in children and adults. Saline irrigation can serve as a safe adjunctive treatment to medication of AR in adults. Saline irrigation can be an alternative therapy for children and pregnant women with AR. Efficacy of hypertonic saline may be better than that of isotonic saline in treating AR of children.
背景
本荟萃分析旨在评估鼻腔盐水冲洗治疗成人和儿童变应性鼻炎（AR）的疗效。
方法
两位作者独立检索了截至 2018 年 12 月的数据库。比较了盐水冲洗与其他治疗方法的疗效差异。对儿童和成人之间效果差异进行了亚组分析。
结果
（1）盐水冲洗与不冲洗相比，在儿童和成人组中，盐水冲洗均显示出显著疗效。（2）盐水+药物与药物相比，在儿童组中，盐水+药物与药物的疗效无统计学差异；在成人组中，盐水+药物的疗效优于药物。（3）盐水冲洗与药物相比，在儿童组中，盐水冲洗与药物的疗效无统计学差异；在成人组中，药物的疗效优于盐水冲洗。（4）高渗盐水与等渗盐水相比，对于儿童，高渗盐水的疗效优于等渗盐水。此外，所有试验中均无成年人报告不良反应。20 名儿童在第一次鼻腔冲洗时报告了不良反应，其中 1 名儿童因不良反应退出。
结论
盐水冲洗可显著改善儿童和成人 AR 的症状。盐水冲洗可作为成人 AR 药物治疗的安全辅助治疗。盐水冲洗可作为儿童和孕妇 AR 的替代疗法。高渗盐水治疗 AR 的疗效可能优于等渗盐水。
Zotero 插件