Jin Ling, Fan Kai, Tan Shiwang, Liu Shangxi, Ge Qin, Wang Yang, Ai Zisheng, Yu Shaoqing
Department of Otolaryngology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People's Republic of China.
Department of Medical Statistics, School of Medicine, Tongji University, Shanghai, 200331, People's Republic of China.
J Inflamm Res. 2022 Jul 15;15:3983-3995. doi: 10.2147/JIR.S365611. eCollection 2022.
Chronic rhinitis (CR) is a common chronic inflammation of the nasal mucosa. Nasal saline irrigation has been demonstrated to be an effective treatment for CR. In this study, we investigated the beneficial effects of hydrogen-rich saline irrigation as an anti-inflammatory irrigation therapy for CR and compared its effectiveness over saline irrigation. Hydrogen-rich saline (HRS) was investigated due to its antioxidant and anti-inflammatory properties.
A total of 120 patients with CR were randomly divided into two groups, patients irrigated with HR (HRS group) and the control group irrigated with saline (NS group). A randomized, double-blind control study was performed. The main observation index in this study was the total score of nasal symptoms (TNSS). In addition, eosinophilic protein (ECP) of the nasal secretions, nasal nitric oxide (nNO) levels, and levels of regulatory T cells (Treg) and regulatory B cells (Breg) were also compared between the two groups. Furthermore, patients with allergic rhinitis (AR) and non-allergic rhinitis (NAR) were also evaluated based on serum-specific IgE positivity.
After treatment, TNSS and nasal ECP in the two groups decreased significantly (P<0.05), with patients in the HRS group showing significantly lower levels compared to the NS group (P<0.05). There were no significant differences in Treg and Breg levels between the two groups. Subgroup analysis showed that TNSS in the AR-HRS group showed a more significant reduction compared to the AR-NS group (P<0.05); however, there were no significant differences for the other inflammatory biomarkers (P>0.05). ECP levels were reduced significantly in the NAR subgroup compared to NS irrigation (P<0.05). There were no obvious adverse events observed in patients during the entire treatment period.
Compared to saline irrigation, HRS nasal irrigation was found to improve CR clinical symptoms, especially in patients with AR. HRS could effectively be used for the clinical treatment of patients with CR.
慢性鼻炎（CR）是鼻黏膜常见的慢性炎症。鼻腔盐水冲洗已被证明是治疗CR的有效方法。在本研究中，我们探讨了富氢盐水冲洗作为CR抗炎冲洗疗法的有益效果，并比较了其与盐水冲洗的有效性。由于富氢盐水（HRS）具有抗氧化和抗炎特性，因此对其进行了研究。
将120例CR患者随机分为两组，一组用富氢盐水冲洗（HRS组），另一组用盐水冲洗作为对照组（NS组）。进行了一项随机、双盲对照研究。本研究的主要观察指标是鼻症状总分（TNSS）。此外，还比较了两组鼻分泌物中的嗜酸性粒细胞蛋白（ECP）、鼻腔一氧化氮（nNO）水平以及调节性T细胞（Treg）和调节性B细胞（Breg）的水平。此外，还根据血清特异性IgE阳性对过敏性鼻炎（AR）和非过敏性鼻炎（NAR）患者进行了评估。
治疗后，两组的TNSS和鼻ECP均显著降低（P<0.05），HRS组患者的水平显著低于NS组（P<0.05）。两组之间Treg和Breg水平无显著差异。亚组分析显示，AR-HRS组的TNSS较AR-NS组降低更显著（P<0.05）；然而，其他炎症生物标志物无显著差异（P>0.05）。与NS冲洗相比，NAR亚组的ECP水平显著降低（P<0.05）。在整个治疗期间，患者未观察到明显不良事件。
与盐水冲洗相比，发现HRS鼻腔冲洗可改善CR临床症状，尤其是AR患者。HRS可有效用于CR患者的临床治疗。
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