不同组织学类型肺癌组织中糖肽的比较。
Comparison of glycopeptide in lung cancer tissues of different histological types.
作者信息
Masuda H, Ozeki T
机构信息
Third Department of Internal Medicine, University of Occupational and Environmental Health, Fukuoka, Japan.
出版信息
Biochem Med Metab Biol. 1988 Dec;40(3):253-9. doi: 10.1016/0885-4505(88)90126-0.
The glycopeptide was studied in the pulmonary cancer tissues of three different histological types including squamous cell carcinoma, undifferentiated cell carcinoma, and adenocarcinoma. The glycopeptide preparation was made by digesting the lung cancer tissues with proteolytic enzymes followed by removal of enzymes and undigested protein. The comparison of the relative proportion of the glycopeptide, which migrated toward the anode slower than hyaluronic acid, and was stained with both alcian blue and PAS, and contained higher sialic acid, was carried out among three different histologic types of lung cancer. This glycopeptide was highest in adenocarcinoma, followed by undifferentiated cell carcinoma, and was lowest in squamous cell carcinoma.
对三种不同组织学类型的肺癌组织（包括鳞状细胞癌、未分化细胞癌和腺癌）中的糖肽进行了研究。糖肽制剂的制备方法是先用蛋白水解酶消化肺癌组织，然后去除酶和未消化的蛋白质。在三种不同组织学类型的肺癌中，对迁移速度比透明质酸慢、同时被阿尔辛蓝和PAS染色且含有较高唾液酸的糖肽的相对比例进行了比较。这种糖肽在腺癌中含量最高，其次是未分化细胞癌，在鳞状细胞癌中含量最低。
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