From the Departments of Radiation Oncology.
Nuclear Medicine and Minnan PET Center, Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University, Teaching Hospital of Fujian Medical University, Xiamen, China.
Clin Nucl Med. 2020 Oct;45(10):e430-e432. doi: 10.1097/RLU.0000000000003015.
Ga-FAPI PET/CT was performed in a 56-year-old cirrhotic patient with multiple liver nodules, which were suspected of hepatocellular carcinoma by contrast-enhanced magnetic resonance but were not visualized by F-FDG PET/CT. Increased Ga-FAPI liver uptake was observed in this cirrhotic patient. However, the nodules had no pathological Ga-FAPI uptake and were clearly visualized due to the low activity compared with surrounding liver parenchyma. The Ga-FAPI PET/CT features, suggestive of benign nodules, have been later confirmed by histopathological examination. This case suggested that Ga-FAPI PET/CT may be useful in the differentiation between benign nodules and hepatocellular carcinoma in the patient with liver cirrhosis.
Ga-FAPI PET/CT 检查在一名 56 岁肝硬化患者中进行，该患者有多个肝脏结节，这些结节在增强磁共振成像时疑似为肝细胞癌，但在 F-FDG PET/CT 上未显示。在这名肝硬化患者中观察到 Ga-FAPI 肝脏摄取增加。然而，由于与周围肝实质相比活性较低，这些结节没有病理性 Ga-FAPI 摄取，并且可以清晰显示。Ga-FAPI PET/CT 的特征提示为良性结节，后来通过组织病理学检查得到证实。该病例提示，Ga-FAPI PET/CT 可能有助于区分肝硬化患者的良性结节和肝细胞癌。
