From the Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou; and Academician (Expert) Workstation of Sichuan Province, Luzhou, Sichuan, People's Republic of China.
Clin Nucl Med. 2021 Jul 1;46(7):589-591. doi: 10.1097/RLU.0000000000003561.
A 65-year-old man with suspected pancreatic cancer underwent 18F-FDG PET/CT for initial staging. Mild FDG uptake was observed in the pancreatic mass and bone destruction in the 10th rib on the right. No significant FDG uptake was seen with the multiple hypodense or isodense nodules in the liver. However, 68Ga-FAPI PET/CT revealed intense FAPI uptake in the pancreas and the 10th rib and multiple lesions in the liver. Finally, a biopsy confirmed carcinoma in the head of the pancreas with liver metastasis. This case highlighted that 68Ga-FAPI may outperform 18F-FDG PET/CT in identifying micrometastases of bones and hidden liver metastases.
一位 65 岁男性疑似患有胰腺癌，进行 18F-FDG PET/CT 初始分期。在胰腺肿块和右侧第 10 肋骨的骨破坏处观察到轻度 FDG 摄取。在肝脏内的多个低或等密度结节中未见明显的 FDG 摄取。然而，68Ga-FAPI PET/CT 显示在胰腺、第 10 肋骨和肝脏内的多个病变中摄取强烈的 FAPI。最后，活检证实胰头癌伴肝转移。本病例提示 68Ga-FAPI 可能优于 18F-FDG PET/CT 识别骨微转移和隐匿性肝转移。
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