RNA 甲基转移酶 NSUN2 通过 mC 依赖性方式抑制 p57 促进胃癌细胞增殖。

RNA methyltransferase NSUN2 promotes gastric cancer cell proliferation by repressing p57 by an mC-dependent manner.

机构信息

Department of General Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, 241001, Wuhu, China.

Department of General Surgery, The First Affiliated Hospital of University of Science and Technology of China, 230001, Hefei, China.

出版信息

Cell Death Dis. 2020 Apr 24;11(4):270. doi: 10.1038/s41419-020-2487-z.

DOI:10.1038/s41419-020-2487-z

PMID:32332707

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7181747/

Abstract

The RNA methyltransferase NSUN2 has been involved in the cell proliferation and senescence, and is upregulated in various types of cancers. However, the role and potential mechanism of NSUN2 in gastric cancer remains to be determined. Our study showed that NSUN2 was significantly upregulated in gastric cancers, compared to adjacent normal gastric tissues. Moreover, NSUN2 could promote gastric cancer cell proliferation both in vitro and in vivo. Further study demonstrated that CDKN1C (p57) was the potential downstream gene of regulated by NSUN2 in gastric cancer. NSUN2 could promote gastric cancer cell proliferation through repressing p57 in an mC-dependent manner. Our findings suggested that NSUN2 acted as an oncogene through promoting gastric cancer development by repressing p57 in an mC-dependent manner, which may provide a novel therapeutic target against gastric cancer.

摘要

RNA 甲基转移酶 NSUN2 参与细胞增殖和衰老，在多种类型的癌症中上调。然而，NSUN2 在胃癌中的作用和潜在机制仍有待确定。我们的研究表明，与相邻的正常胃组织相比，NSUN2 在胃癌中显著上调。此外，NSUN2 可以促进胃癌细胞在体外和体内的增殖。进一步的研究表明，CDKN1C（p57）是 NSUN2 在胃癌中调控的潜在下游基因。NSUN2 通过依赖 mC 的方式抑制 p57 来促进胃癌细胞增殖。我们的研究结果表明，NSUN2 通过依赖 mC 的方式抑制 p57 来促进胃癌的发生，从而充当致癌基因，这可能为治疗胃癌提供新的靶点。