Saranza Gerard, Lang Anthony E
Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, ON, Canada.
Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
J Neurol. 2021 Sep;268(9):3135-3143. doi: 10.1007/s00415-020-09810-7. Epub 2020 Apr 24.
A drug challenge test in Parkinson's disease, such as the levodopa challenge test (LCT), is an easy and generally safe procedure, which has been used by clinicians for various indications. The results of the test have significant implications in the management of patients, from preoperative evaluation for deep brain stimulation to providing the basis for medication adjustments to address motor or non-motor fluctuations and dyskinesias. This paper reviews the different indications and protocols commonly used in an acute LCT. Potential complications of the procedure and an overview of levodopa responsiveness and unresponsiveness are also discussed.
帕金森病的药物激发试验，如左旋多巴激发试验（LCT），是一种简单且总体安全的程序，临床医生已将其用于各种适应症。该试验结果对患者的管理具有重要意义，从用于深部脑刺激的术前评估到为药物调整提供依据，以解决运动或非运动波动及异动症。本文回顾了急性LCT中常用的不同适应症和方案。还讨论了该程序的潜在并发症以及左旋多巴反应性和无反应性的概述。
