Herbig Elisa, Mücke Doris, Barbe Michael T, Thies Tabea
IfL-Phonetik, Faculty of Arts and Humanities, University of Cologne, Cologne, Germany.
Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Front Hum Neurosci. 2025 Jul 2;19:1580376. doi: 10.3389/fnhum.2025.1580376. eCollection 2025.
This study investigates the effects of executive functions and levodopa on articulatory timing patterns in simple and complex syllable onsets (CV vs. CCV) in Parkinson's disease (PD). Kinematic speech data (EMA) of 25 individuals with PD in medication-OFF as well as medication-ON condition and 25 healthy controls (HC) were recorded, and group differences were examined. Results showed preserved articulatory coordination that is skewed in time in the PD group as well as a positive effect of levodopa on these patterns. Cluster analysis revealed an age-dependent decline in executive functions across groups that correlated with the shift pattern of the second consonant in CCV sequences for the PD group. This indicates that executive dysfunctions could give rise to changes in articulatory timing patterns as the disease progresses but independently of general motor severity.
本研究调查了执行功能和左旋多巴对帕金森病（PD）患者简单和复杂音节起始（CV与CCV）时发音时间模式的影响。记录了25名处于未服药状态和服药状态的PD患者以及25名健康对照（HC）的运动语音数据（电磁发音仪），并检查了组间差异。结果显示，PD组存在发音协调性，且时间上有偏差，同时左旋多巴对这些模式有积极作用。聚类分析显示，各组执行功能随年龄下降，且与PD组CCV序列中第二个辅音的移位模式相关。这表明，随着疾病进展，执行功能障碍可能导致发音时间模式的改变，但与一般运动严重程度无关。
