Department of Pathology, University College of Medical Sciences & Guru Teg Bahadur Hospital, University of Delhi, Delhi 110095, India; Department of Pathology, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, India(1).
Department of Pathology, University College of Medical Sciences & Guru Teg Bahadur Hospital, University of Delhi, Delhi 110095, India.
Diabetes Res Clin Pract. 2020 May;163:108156. doi: 10.1016/j.diabres.2020.108156. Epub 2020 Apr 22.
By virtue of its role in oxidized low-density lipoprotein uptake and foam cell transformation, monocyte CD36 (mCD36) is a potential non-invasive tool to detect atherosclerosis (ATH) in patients of type 2 diabetes mellitus (DM).
Flowcytometric expression of mCD36 was evaluated with reference to ankle brachial index (ABI) in 70 patients of type 2 DM [40 with and 30 without coronary artery disease (CAD) respectively] and 30 age and gender matched normoglycemic controls (NGCs).
DM patients had significantly higher mCD36 indices than NGCs (p < 0.001). The mCD36 expression was significantly higher in DM persons with CAD and those with poor glycemia control (glycosylated haemoglobin, HbA1c ≥ 7%) than their respective counterparts (p < 0.001 for both). Thirty subjects had compromised ABI (≤0.9); all were DM persons with CAD. ABI compromised subjects had consistently higher mCD36 indices than all other sub-groups (p < 0.001 for all comparisons). Notably, within the ABI-uncompromised group, mCD36 indices differed significantly and showed progressive increase from NGCs to diabetics without and with CAD respectively.
mCD36 plays an important role in atherogenesis. With reference to ABI, mCD36 performed robustly as a marker of ATH. Furthermore, it could stratify subjects within the 'ABI-uncompromised group' commensurate with their conventional clinico-pathological ATH risk predisposition.
由于其在氧化型低密度脂蛋白摄取和泡沫细胞转化中的作用，单核细胞 CD36（mCD36）是一种潜在的非侵入性工具，可用于检测 2 型糖尿病患者的动脉粥样硬化（ATH）。
通过与踝臂指数（ABI）进行比较，评估 70 例 2 型糖尿病患者（分别为 40 例有和 30 例无冠状动脉疾病（CAD））和 30 例年龄和性别匹配的正常血糖对照者（NGCs）的 mCD36 表达。
与 NGC 相比，DM 患者的 mCD36 指数明显更高（p<0.001）。DM 合并 CAD 患者和血糖控制不佳（糖化血红蛋白，HbA1c≥7%）患者的 mCD36 表达明显高于各自的对照组（均为 p<0.001）。30 例患者的 ABI 受损（≤0.9）；均为合并 CAD 的 DM 患者。ABI 受损患者的 mCD36 指数始终高于其他所有亚组（所有比较均为 p<0.001）。值得注意的是，在 ABI 正常组中，mCD36 指数差异显著，且与 NGC 相比，无 CAD 和有 CAD 的糖尿病患者分别呈逐渐升高趋势。
mCD36 在动脉粥样硬化形成中起重要作用。参考 ABI，mCD36 作为 ATH 的标志物表现稳健。此外，它可以根据传统的临床病理 ATH 风险倾向对“ABI 正常组”内的患者进行分层。
