Department of Endocrinology, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Road, Shanghai, 200040, China.
Department of Endocrinology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China.
BMC Cardiovasc Disord. 2020 Apr 25;20(1):198. doi: 10.1186/s12872-020-01456-7.
Heat shock protein 27 (HSP27) has been proposed as a vital protective factor in atherosclerosis. The objective of the present study was to evaluate the association between circulating HSP27 and carotid intima-media thickness (IMT) in individuals with type 2 diabetes and to determine whether HSP27 represents an independent marker of subclinical atherosclerosis in this patient population.
We performed a cross-sectional community-based study in 186 Chinese subjects with a median duration of type 2 diabetes of 8.2 years who underwent ultrasound carotid IMT measurement. Serum HSP27 levels were assessed by ELISA.
Serum HSP27 levels were significantly higher in the IMT (+, > 1.0 mm) group than in the IMT (-, ≤1.0 mm) group, with the median values of 8.80 ng/mL (5.62-12.25) and 6.93 ng/mL (4.23-9.60), respectively (P = 0.006). The discriminative value of HSP27 to evaluate IMT was 7.16 ng/mL and the area under the curve was 0.72 (95%CI = 0.64-0.80, P = 0.0065). Spearman's rank correlation analysis demonstrated that the concentrations of circulating HSP27 were positively associated with carotid IMT (r = 0.198, P = 0.007) and blood urea nitrogen (r = 0.170, P < 0.05). Furthermore, in the logistic model, serum HSP27 levels were found to be independent predictors for carotid IMT in type 2 diabetic patients after adjustment for onset age of diabetes, blood pressure, total cholesterol and C-reactive protein (OR = 1.085, P = 0.022).
Circulating HSP27, positively correlates with carotid IMT, is an independent predictor for early atherosclerotic changes in diabetes, and may represent a novel marker of subclinical atherosclerosis in type 2 diabetes.
热休克蛋白 27（HSP27）被认为是动脉粥样硬化的重要保护因子。本研究的目的是评估 2 型糖尿病患者循环 HSP27 与颈动脉内膜中层厚度（IMT）之间的关系，并确定 HSP27 是否代表该患者人群亚临床动脉粥样硬化的独立标志物。
我们在中国进行了一项横断面社区研究，共纳入 186 名中位病程为 8.2 年的 2 型糖尿病患者，这些患者均接受了超声颈动脉 IMT 测量。通过 ELISA 法评估血清 HSP27 水平。
IMT（+，>1.0mm）组的血清 HSP27 水平明显高于 IMT（-，≤1.0mm）组，中位数分别为 8.80ng/ml（5.62-12.25）和 6.93ng/ml（4.23-9.60）（P=0.006）。HSP27 评估 IMT 的临界值为 7.16ng/ml，曲线下面积为 0.72（95%CI=0.64-0.80，P=0.0065）。Spearman 秩相关分析显示，循环 HSP27 浓度与颈动脉 IMT 呈正相关（r=0.198，P=0.007）和血尿素氮（r=0.170，P<0.05）。此外，在逻辑回归模型中，在校正糖尿病发病年龄、血压、总胆固醇和 C 反应蛋白后，血清 HSP27 水平被发现是 2 型糖尿病患者颈动脉 IMT 的独立预测因子（OR=1.085，P=0.022）。
循环 HSP27 与颈动脉 IMT 呈正相关，是糖尿病早期动脉粥样硬化变化的独立预测因子，可能代表 2 型糖尿病亚临床动脉粥样硬化的新标志物。
