Department of Public Health, Shihezi University School of Medicine, Shihezi, China.
BMC Public Health. 2020 Apr 25;20(1):553. doi: 10.1186/s12889-020-08612-w.
Metabolic syndrome is diagnosed by a cluster of risk factors that associated with an increased risk of coronary heart disease (CHD). We aimed to explore the impact of and interactions between individual metabolic syndrome components on the risk of CHD in Xinjiang.
The baseline population included 7635 participants. The degree to which the components increase the risk of CHD and the multiplicative interactions between them were assessed using hazard ratios (HRs) and 95% confidence intervals (CIs). Additive interactions were appraised by the relative excess risk due to interaction, synergy index (SI), and attributable proportion of interaction.
A total of 304 CHD patients were enrolled from rural residents of Xinjiang. Elevated blood pressure (HR 1.81; 95% CI 1.35-2.44) and elevated fasting blood glucose (FBG) (HR 1.82; 95% CI 1.38-2.38) increased the risk of CHD after adjustment for confounding factors. We found a positive additive interaction (SI 1.14; 95% CI 0.51-2.51) between elevated blood pressure and elevated FBG, but none were significant. As the number of components increased, the risk of CHD increased. The combinations of [high triglycerides (TG) + low high-density lipoprotein cholesterol (HDL-C) + elevated FBG + large waistline] (HR 4.26; 95% CI 1.43-12.73) and [elevated blood pressure + elevated FBG + low HDL-C + large waistline] (HR 1.82; 95% CI 1.38-2.38) increased the risk of CHD.
We provide evidence that elevated blood pressure and elevated FBG are independent risk factors for CHD and it might be necessary to maintain the normal waistline for preventing CHD.
代谢综合征是通过一组与冠心病（CHD）风险增加相关的危险因素来诊断的。我们旨在探讨新疆个体代谢综合征成分对 CHD 风险的影响及其相互作用。
基础人群包括 7635 名参与者。使用风险比（HR）和 95%置信区间（CI）评估各成分增加 CHD 风险的程度以及它们之间的乘法相互作用。通过交互超额相对危险度、协同指数（SI）和交互归因比例评估附加相互作用。
共纳入新疆农村居民 304 例 CHD 患者。调整混杂因素后，高血压（HR 1.81；95%CI 1.35-2.44）和空腹血糖升高（HR 1.82；95%CI 1.38-2.38）均增加 CHD 风险。我们发现高血压和空腹血糖升高之间存在正相加相互作用（SI 1.14；95%CI 0.51-2.51），但均无统计学意义。随着成分数量的增加，CHD 的风险增加。[高甘油三酯（TG）+低高密度脂蛋白胆固醇（HDL-C）+空腹血糖升高+大腰围]（HR 4.26；95%CI 1.43-12.73）和[高血压+空腹血糖升高+低 HDL-C+大腰围]（HR 1.82；95%CI 1.38-2.38）的组合增加 CHD 风险。
我们提供的证据表明，高血压和空腹血糖升高是 CHD 的独立危险因素，为预防 CHD 可能有必要保持正常腰围。
