Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC, Australia; La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC, Australia.
Int Rev Cell Mol Biol. 2020;352:115-158. doi: 10.1016/bs.ircmb.2020.01.003. Epub 2020 Feb 5.
The fate of a cell is determined by multiple signaling pathways in response to a range of stimuli. Probably the most prominent cell death mechanism is apoptosis which can be triggered by both internal stresses, as well as extracellular stimuli, and is executed by two well-characterized pathways, the intrinsic and the extrinsic apoptosis pathways. Although autophagy can also lead to cell death under certain circumstances, its major function is as a cell survival process. Given that the life of a cell is at stake, it is not surprising that there is significant molecular crosstalk between these pathways. The nature of these interconnections is diverse and ranges from protein-protein interactions and post-translational modifications through to the degradation of molecular components by different proteins and organelles. In this chapter we review these mechanisms in detail.
细胞的命运是由多种信号通路决定的，这些信号通路会对各种刺激做出反应。可能最突出的细胞死亡机制是细胞凋亡，它可以由内部压力以及细胞外刺激触发，并由两种特征明确的途径执行，即内在和外在细胞凋亡途径。尽管自噬在某些情况下也可能导致细胞死亡，但它的主要功能是作为一种细胞存活过程。考虑到细胞的生命处于危险之中，这些途径之间存在显著的分子串扰也就不足为奇了。这些相互联系的性质多种多样，范围从蛋白质-蛋白质相互作用和翻译后修饰到不同蛋白质和细胞器对分子成分的降解。在本章中，我们将详细回顾这些机制。
