Research & Translational Development, Sensorion SA, 375 rue du Professeur Joseph Blayac, Montpellier, France.
Department of Physiology and Pharmacology, KarolinskaInstitutet, Solnavägen 9, Stockholm, Sweden.
Otolaryngol Clin North Am. 2020 Aug;53(4):651-666. doi: 10.1016/j.otc.2020.03.012. Epub 2020 Apr 23.
Despite recent, major steps forward in our understanding of tinnitus pathophysiology and improved research methodology, tinnitus remains a clear unmet clinical need. Here, the authors identify current active clinical and preclinical development programs of tinnitus drug candidates using publications, databases, and company communications. The current drug development programs hold promise for new therapeutic options for tinnitus patients, but further fundamental research is needed to validate additional targets for treating tinnitus.
尽管我们最近在耳鸣生理学的理解上取得了重大进展,并改进了研究方法,但耳鸣仍然是一个明显未满足的临床需求。在这里,作者使用出版物、数据库和公司通讯来确定当前耳鸣候选药物的活跃临床前和临床开发计划。当前的药物开发计划为耳鸣患者提供了新的治疗选择的希望,但需要进一步的基础研究来验证治疗耳鸣的其他靶点。