Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
Member Expert Panel, Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Ave., New York, NY, 10032, USA.
Food Chem Toxicol. 2020 Jul 15;141 Suppl 1:111338. doi: 10.1016/j.fct.2020.111338. Epub 2020 Apr 24.
The existing information supports the use of this material as described in this safety assessment. p-Isopropylbenzyl alcohol was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from the read-across analog benzyl alcohol (CAS # 100-51-6) show that p-isopropylbenzyl alcohol is not expected to be genotoxic. Data from the read-across analog benzyl alcohol (CAS # 100-51-6) provide a calculated MOE >100 for the repeated dose, developmental, and local respiratory toxicity endpoints. The reproductive toxicity endpoint was evaluated using the TTC for a Cramer Class I material, and the exposure is below the TTC (0.03 mg/kg/day). Data from read-across analog benzyl alcohol (CAS # 100-51-6) provided p-isopropylbenzyl alcohol a NESIL of 5900 μg/cm for the skin sensitization endpoint. The phototoxicity and photoallergenicity endpoints were evaluated based on UV spectra; p-isopropylbenzyl alcohol is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; p-isopropylbenzyl alcohol was found not to be a PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC) are <1.
现有信息支持将该材料用于本安全性评估中所述用途。异丙基苄醇已针对遗传毒性、重复剂量毒性、发育和生殖毒性、局部呼吸毒性、光毒性/光过敏、皮肤致敏和环境安全性进行了评估。来自类似物苄醇（CAS # 100-51-6）的可推断数据表明，异丙基苄醇预计不会具有遗传毒性。来自类似物苄醇（CAS # 100-51-6）的可推断数据为重复剂量、发育和局部呼吸毒性终点提供了计算出的 MOE > 100。生殖毒性终点使用 TTC 进行了评估，因为它是 Cramer 分类 I 物质，并且暴露量低于 TTC（0.03 mg/kg/天）。来自类似物苄醇（CAS # 100-51-6）的可推断数据为皮肤致敏终点提供了异丙基苄醇的 NESIL 值为 5900μg/cm。光毒性和光过敏终点是基于 UV 光谱进行评估的；异丙基苄醇预计不会具有光毒性/光过敏。已对环境终点进行了评估；根据 IFRA 环境标准，异丙基苄醇不属于 PBT，并且根据其在欧洲和北美的当前用量（即 PEC/PNEC），其风险商数<1。
