Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.
Member Expert Panel, Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Ave., New York, NY, 10032, USA.
Food Chem Toxicol. 2020 Jul 15;141 Suppl 1:111337. doi: 10.1016/j.fct.2020.111337. Epub 2020 Apr 24.
The existing information supports the use of this material as described in this safety assessment. Cinnamyl alcohol was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization, and environmental safety. Data show that cinnamyl alcohol is not genotoxic. Data on read-across analog cinnamaldehyde (CAS # 104-55-2) provide a calculated margin of exposure (MOE) >100 for the repeated dose and local respiratory toxicity endpoints. The developmental and reproductive toxicity endpoint was evaluated using the threshold of toxicological concern (TTC) for a Cramer Class I material, and the exposure to cinnamyl alcohol is below the TTC (0.03 mg/kg/day). Data provided a No Expected Sensitization Induction Level (NESIL) of 2900 μg/cm for the skin sensitization endpoint. The phototoxicity/photoallergenicity endpoints were evaluated based on UV spectra; cinnamyl alcohol is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; cinnamyl alcohol was found not to be persistent, bioaccumulative, and toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.
现有信息支持在本安全评估中对该材料进行描述。已对肉桂醇进行遗传毒性、重复剂量毒性、发育毒性、生殖毒性、局部呼吸毒性、光毒性、皮肤致敏性和环境安全性评估。数据表明肉桂醇没有遗传毒性。经结构类似物肉桂醛（CAS#104-55-2）的相关数据提供了重复剂量和局部呼吸毒性终点的计算暴露量（MOE）>100。发育和生殖毒性终点是使用毒性关注阈值（TTC）来评估的，对于 Cramer 分类 I 物质，肉桂醇的暴露量低于 TTC（0.03mg/kg/day）。皮肤致敏性终点提供了 2900μg/cm 的无预期致敏诱导水平（NESIL）数据。光毒性/光致敏性终点是根据紫外线光谱进行评估的；肉桂醇预计不会具有光毒性/光致敏性。对环境终点进行了评估；肉桂醇被发现不具有持久性、生物累积性和毒性（PBT），符合国际香料协会（IFRA）的环境标准，并且根据其在欧洲和北美的当前用量，其风险商数（基于预测环境浓度/无效应预测浓度 [PEC/PNEC]）<1。
