University of Groningen, University Medical Center Groningen, Department of Paediatrics, Division of Developmental Neurology, Groningen, The Netherlands.
Department of General Practice and Elderly Care Medicine, Amsterdam UMC, Amsterdam, The Netherlands.
Acta Paediatr. 2020 Dec;109(12):2762-2769. doi: 10.1111/apa.15329. Epub 2020 May 13.
To determine the prevalence of atypical general movements (GMs) in the general population, to examine its time trend and associated factors.
Participants consisted of 300 infants born in 2016-2018 (current cohort; gestational age 39.4 weeks (27-42); 162 boys), representative of the Dutch population. GMs were assessed at 2-4 months corrected age in terms of GM-complexity (definitely abnormal (DA) or not) and fidgety movements (present or absent). GM-complexity data from a cohort of 455 Dutch infants born in 2001-2002 were used to investigate the time trend.
In the current cohort, 10 infants (3%) showed DA GM-complexity and 8 (3%) absent fidgety movements. Only one infant had both GM-impairments (0.3%). The prevalence of DA GM-complexity did not differ from that in the 2001-2002 cohort (adjusted odds ratio (OR) = 1.47 [0.53, 4.06]). DA GM-complexity was associated with maternal smoking (adjusted OR = 3.59 [1.56, 8.28]) and marginally with prematurity (adjusted OR = 2.78 [1.00, 7.74]); absence of fidgety movements was curvilinearly associated with assessment age only (OR = 1.06 [1.01, 1.12]).
In the general population, the prevalence of DA GM-complexity and absent fidgety movements is 3%. The finding that they rarely co-occur and are associated with different factors indicates that GM-assessment needs to address both aspects.
确定一般人群中不典型一般运动（GM）的患病率，研究其时间趋势和相关因素。
参与者包括 2016-2018 年出生的 300 名婴儿（当前队列；胎龄 39.4 周（27-42）；162 名男孩），代表荷兰人群。GM 于 2-4 个月校正年龄时进行评估，包括 GM 复杂性（明确异常（DA）或无）和烦躁运动（存在或不存在）。使用 2001-2002 年出生的 455 名荷兰婴儿队列的 GM 复杂性数据来研究时间趋势。
在当前队列中，10 名婴儿（3%）表现出 DA GM 复杂性，8 名婴儿（3%）烦躁运动缺失。只有一名婴儿同时存在两种 GM 损伤（0.3%）。DA GM 复杂性的患病率与 2001-2002 年队列无差异（调整后优势比（OR）=1.47 [0.53, 4.06]）。DA GM 复杂性与母亲吸烟有关（调整后 OR=3.59 [1.56, 8.28]），且与早产呈边缘相关（调整后 OR=2.78 [1.00, 7.74]）；烦躁运动缺失仅与评估年龄呈曲线相关（OR=1.06 [1.01, 1.12]）。
在一般人群中，DA GM 复杂性和烦躁运动缺失的患病率为 3%。发现它们很少同时发生，且与不同因素相关，表明 GM 评估需要同时考虑这两个方面。
