Institute of Molecular Oncology, Göttingen Center of Molecular Biosciences (GZMB), University Medical Center Göttingen, Göttingen, Germany.
Institute for Advanced Study, Princeton, NJ, USA.
Cancer Sci. 2020 Jul;111(7):2203-2211. doi: 10.1111/cas.14433. Epub 2020 Jun 11.
The Mdm2 oncoprotein and its association with p53 were discovered 30 years ago, and a cornucopia of activities and regulatory pathways have been associated with it. In this review, we will raise questions about Mdm2 and its cousin Mdm4 that we consider worth pursuing in future research, reaching from molecular structures and intracellular activities all the way to development, evolution, and cancer therapy. We anticipate that such research will not only close a few gaps in our knowledge but could add new dimensions to our current view. This compilation of questions contributes to the preparation for the 10th Mdm2 Workshop in Tokyo.
Mdm2 癌蛋白及其与 p53 的关联在 30 年前被发现，此后与之相关的活动和调控途径层出不穷。在这篇综述中，我们将提出一些关于 Mdm2 及其同源物 Mdm4 的问题，这些问题是我们认为值得在未来的研究中探讨的，涵盖了从分子结构和细胞内活动到发育、进化和癌症治疗的各个方面。我们预计，这类研究不仅能够填补我们知识体系中的一些空白，还能为我们现有的认识增添新的维度。这些问题的提出是为了筹备在东京举行的第十届 Mdm2 研讨会。
