Department of Neuroscience, The Scripps Research Institute, Jupiter, Florida, 33458, USA.
Neural Dev. 2020 Apr 26;15(1):6. doi: 10.1186/s13064-020-00143-9.
Huwe1 is a highly conserved member of the HECT E3 ubiquitin ligase family. Here, we explore the growing importance of Huwe1 in nervous system development, function and disease. We discuss extensive progress made in deciphering how Huwe1 regulates neural progenitor proliferation and differentiation, cell migration, and axon development. We highlight recent evidence indicating that Huwe1 regulates inhibitory neurotransmission. In covering these topics, we focus on findings made using both vertebrate and invertebrate in vivo model systems. Finally, we discuss extensive human genetic studies that strongly implicate HUWE1 in intellectual disability, and heighten the importance of continuing to unravel how Huwe1 affects the nervous system.
Huwe1 是 HECT E3 泛素连接酶家族中高度保守的成员。在这里，我们探讨了 Huwe1 在神经系统发育、功能和疾病中的重要性不断增加。我们讨论了在阐明 Huwe1 如何调节神经祖细胞增殖和分化、细胞迁移和轴突发育方面所取得的广泛进展。我们强调了最近的证据表明 Huwe1 调节抑制性神经传递。在涵盖这些主题时，我们专注于使用脊椎动物和无脊椎动物体内模型系统所获得的发现。最后，我们讨论了大量的人类遗传研究，这些研究强烈表明 HUWE1 与智力障碍有关，并强调了继续阐明 Huwe1 如何影响神经系统的重要性。
