原始滤泡性淋巴瘤的细胞遗传学特征和临床意义。
Blastic Plasmacytoid Dendritic Cell Neoplasm: Clinical Presentation and Diagnosis.
机构信息
Service Hématologie, Université de Bourgogne Franche-Comté, INSERM Unite Mixte de Recherche (UMR) 1098, RIGHT Interactions Greffon-Hôte-Tumeur/Ingénierie Cellulaire et Génique, Centre Hospitalier Universitaire de Besançon, 3 Boulevard Alexandre Fleming, Besançon Cedex 25030, France.
Department of Pathology, University of Montréal, Hôpital Maisonneuve-Rosemont, 2900 Boulevard Edouard-Montpetit, Montréal QC H3T 1J4, Quebec, Canada.
出版信息
Hematol Oncol Clin North Am. 2020 Jun;34(3):491-500. doi: 10.1016/j.hoc.2020.01.010. Epub 2020 Mar 23.
Clinical and biological presentation of patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN) is depicted to highlight criteria that might alert physicians. Diagnosis of BPDCN is still challenging and requires (1) immunophenotyping of blood or bone marrow aspiration using several markers (CD4, CD56, HLA-DR, myeloid and lymphoid lineage markers) and should include pDC markers such as CD123, cTCL1, CD303, and CD304, and/or (2) pathologic analysis of cutaneous lesions, also with immunohistochemistry using markers specific to BPDCN.
患者的临床和生物学表现 浆母细胞性树突细胞肿瘤（BPDCN）旨在突出可能提示医生的标准。BPDCN 的诊断仍然具有挑战性，需要（1）使用多种标记物（CD4、CD56、HLA-DR、髓系和淋巴系标记物）对血液或骨髓抽吸物进行免疫表型分析，并应包括 pDC 标记物，如 CD123、cTCL1、CD303 和 CD304，和/或（2）皮肤病变的病理分析，也使用针对 BPDCN 的特异性标记物进行免疫组织化学分析。
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