针对原始浆细胞样树突细胞肿瘤的 CD123 靶向免疫疗法。
Immunotherapies Targeting CD123 for Blastic Plasmacytoid Dendritic Cell Neoplasm.
机构信息
Department of Hematology & Hematology Cell Transplantation, City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA; Department of Molecular Medicine, Beckman Research Institute, City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA; T Cell Therapeutics Research Laboratory, Beckman Research Institute, City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA; Irell & Manella Graduate School of Biological Sciences, Beckman Research Institute, City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA.
Department of Hematology & Hematology Cell Transplantation, City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA; T Cell Therapeutics Research Laboratory, Beckman Research Institute, City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA; Irell & Manella Graduate School of Biological Sciences, Beckman Research Institute, City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA.
出版信息
Hematol Oncol Clin North Am. 2020 Jun;34(3):575-587. doi: 10.1016/j.hoc.2020.01.006. Epub 2020 Mar 27.
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, difficult-to-diagnose, highly aggressive myeloid malignancy with poor prognosis and no standard of care. The interleukin-3 receptor α, or CD123, is highly expressed in patients with myeloid malignancies, particularly acute myeloid leukemia and BPDCN. CD123 is overexpressed on leukemic stem cells compared with normal hematopoietic stem cells, suggesting CD123 as an attractive immunotherapeutic target. To date, multiple CD123-targeted therapeutic avenues have been explored to treat BPDCN and other CD123 hematologic malignancies. This review summarizes immunotherapies targeting CD123 for the treatment of BPDCN and related neoplasms.
原始浆细胞样树突细胞肿瘤（BPDCN）是一种罕见的、难以诊断的、侵袭性强的髓系恶性肿瘤，预后差，目前尚无标准治疗方法。白细胞介素 3 受体α（也称为 CD123）在髓系恶性肿瘤患者中高度表达，尤其是急性髓系白血病和 BPDCN。与正常造血干细胞相比，CD123 在白血病干细胞上过度表达，提示 CD123 是一种有吸引力的免疫治疗靶点。迄今为止，已经探索了多种针对 CD123 的治疗方法来治疗 BPDCN 和其他 CD123 血液系统恶性肿瘤。本文总结了针对 CD123 的免疫疗法在治疗 BPDCN 和相关肿瘤中的应用。
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