Guan Xuan, Jalil Anum, Khanal Kishor, Liu Baoqiong, Jain Akriti G
Internal Medicine, AdventHealth, Orlando, USA.
Cureus. 2020 Mar 25;12(3):e7418. doi: 10.7759/cureus.7418.
Cardiac tumors are extremely rare. Here, we report an unusual case of cardiac plasmacytoma that occurred 11 years after complete remission of the original multiple myeloma (MM). The tumor primarily manifested as a solitary extramedullary plasmacytoma (SEP) with extensive infiltration into the heart and large vessels. There was no evidence of systemic involvement. The relapsing tumor assumed a unique immunophenotype from CD138+/CD38+/CD56- to CD138-/CD38+/CD56-. The patient responded to chemotherapy consisting of carfilzomib, cyclophosphamide, and dexamethasone. This case highlights the importance of multimodal imaging evaluation and tissue diagnosis for accurately characterizing this rare disorder.
心脏肿瘤极为罕见。在此，我们报告一例不寻常的心脏浆细胞瘤病例，该病例发生于原多发性骨髓瘤（MM）完全缓解11年后。肿瘤主要表现为孤立性髓外浆细胞瘤（SEP），并广泛浸润心脏和大血管。无全身受累证据。复发肿瘤呈现出从CD138+/CD38+/CD56-到CD138-/CD38+/CD56-的独特免疫表型。患者对由卡非佐米、环磷酰胺和地塞米松组成的化疗有反应。该病例凸显了多模态影像评估和组织诊断对于准确鉴别这种罕见疾病的重要性。
