Zhao Xiaoxian, Liu Jie, Xu Zhenju, Chen Lifang, Zang Chuanshan, Xie Feng, Bai Shizeyu, Ma Shihui, Han Min
Department of Otorhinolaryngology Head and Neck Surgery，the Affiliated Hospital of Qingdao University，Qingdao，266000，China.
Department of Pathology，the Affiliated Hospital of Qingdao University.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2024 Oct;38(10):970-974. doi: 10.13201/j.issn.2096-7993.2024.10.017.
In order to better understand the condition and provide the groundwork for early detection and treatment of plasmacytomas, it is important to examine the clinical characteristics, therapeutic options, and effectiveness of plasmacytomas that are initially identified with head and neck symptoms. Retrospective analysis, evaluation, and discussion of the clinical data of 7 patients with plasmacytoma initially diagnosed with head and neck symptoms and admitted to the Affiliated Hospital of Qingdao University during the period of June 2013 to November 2022 was done in combination with pertinent literature. All seven patients were diagnosed with plasmacytoma by histopathology, with lesions located in the nasopharyngeal oropharynx in 4 cases, nasal sinuses in 2 cases, and ventricular zone in 1 case. Clinical manifestations and imaging were atypical, with localized manifestations, of which 2 cases were accompanied by multiple skeletal lesions throughout the body, and 4 cases had lymph node metastasis. Surgery was preferred for all patients, and individualized treatment was recommended after surgery. Of the 7 patients, 3 patients underwent surgery and chemotherapy, 2 patients underwent surgery and radiotherapy and chemotherapy, 1 patient underwent surgery and radiotherapy, and 1 case was treated with surgery only. The follow-up period was 3-60 months, with a 100% follow-up rate. 5 cases were alive and 2 cases died of multiple myeloma after 4-5 years Plasmacytomas first diagnosed with head and neck symptoms are rare, and extramedullary plasmacytomas have a better prognosis, while more advanced multiple myeloma has a poorer prognosis; Therefore, enhancing the quality of survival as well as the duration of survival for patients with plasmacytomas requires early diagnosis and individualized treatment.
为了更好地了解浆细胞瘤的病情，并为其早期发现和治疗奠定基础，研究最初表现为头颈部症状的浆细胞瘤的临床特征、治疗方案及疗效具有重要意义。结合相关文献，对2013年6月至2022年11月期间青岛大学附属医院收治的7例最初诊断为头颈部症状的浆细胞瘤患者的临床资料进行回顾性分析、评估和讨论。7例患者均经组织病理学确诊为浆细胞瘤，病变位于鼻咽口咽部4例，鼻窦2例，脑室区1例。临床表现及影像学表现均不典型，以局部表现为主，其中2例伴有全身多发骨骼病变，4例有淋巴结转移。所有患者均首选手术治疗，术后建议个体化治疗。7例患者中，3例行手术及化疗，2例行手术及放疗加化疗，1例行手术及放疗，1例仅行手术治疗。随访时间3 - 60个月，随访率100%。5例存活，2例在4 - 5年后死于多发性骨髓瘤。最初诊断为头颈部症状的浆细胞瘤较为罕见，髓外浆细胞瘤预后较好，而晚期多发性骨髓瘤预后较差；因此，提高浆细胞瘤患者的生存质量及生存期需要早期诊断和个体化治疗。
