Gauthier Amanda, Simic Nevena, Jones Kevin C, RamachandranNair Rajesh
Niagara Health, Welland, Ontario, Canada.
Comprehensive Pediatric Epilepsy Program, McMaster Children's Hospital, Hamilton, Ontario, Canada.
Epilepsy Behav Rep. 2019 Dec 19;13:100353. doi: 10.1016/j.ebr.2019.100353. eCollection 2020.
Typically, the amount of daily carbohydrate in the Modified Atkins diet (MAD) is restricted to 10-20 g from the beginning of the therapy. It is possible to gradually reduce the daily carbohydrate amount to this target to increase acceptability of the diet. We report the use of the MAD with slow carbohydrate reduction in a patient with Glucose Transporter 1 Deficiency, including results of neuropsychological assessments. Seizures were controlled at 45 g of carbohydrates daily. This case report illustrates that a liberalized form of MAD with slow reduction of carbohydrate may be a therapeutic option in some children with epilepsy. It is possible that other children with epilepsy could achieve seizure control at higher carbohydrate level than current MAD recommendations.
通常，改良阿特金斯饮食（MAD）从治疗开始时起，每日碳水化合物摄入量就限制在10 - 20克。可以逐渐将每日碳水化合物量减少至该目标，以提高饮食的可接受性。我们报告了在一名葡萄糖转运蛋白1缺乏症患者中使用缓慢减少碳水化合物的MAD，包括神经心理学评估结果。癫痫发作在每日45克碳水化合物时得到控制。本病例报告表明，一种碳水化合物缓慢减少的宽松形式的MAD可能是一些癫痫患儿的治疗选择。其他癫痫患儿有可能在高于当前MAD建议的碳水化合物水平时实现癫痫发作控制。
