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Serum procollagen III N-terminal peptide and laminin P1 fragment concentrations in alcoholic liver disease and primary biliary cirrhosis.

作者信息

van Zanten R A, van Leeuwen R E, Wilson J H

机构信息

Department of Internal Medicine II, University Hospital Dijkzigt, Rotterdam, The Netherlands.

出版信息

Clin Chim Acta. 1988 Oct 14;177(2):141-6. doi: 10.1016/0009-8981(88)90135-0.

DOI:10.1016/0009-8981(88)90135-0
PMID:3233763
Abstract

Procollagen type III N-peptide (PIII NP) and laminin P1 fragment (LP1) have both been proposed as markers of liver fibrosis. In this study we evaluated the diagnostic application of both peptides in alcoholic liver disease and primary biliary cirrhosis. Serum concentrations of the peptides were measured by radioimmunoassay. PIII NP and LP1 levels appeared to be significantly raised in patients with alcoholic and primary biliary cirrhosis. Patients with alcohol abuse without cirrhosis had normal or slightly elevated PIII NP levels, but significantly raised LP1 levels. There was a strong correlation between PIII NP and LP1 concentrations.

摘要

相似文献

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Serum procollagen III N-terminal peptide and laminin P1 fragment concentrations in alcoholic liver disease and primary biliary cirrhosis.
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2
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