Department of Anaesthetics, University College Hospital, London, UK.
William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK.
Br J Hosp Med (Lond). 2020 Apr 2;81(4):1-9. doi: 10.12968/hmed.2020.0045. Epub 2020 Apr 14.
Muscle wasting in critically ill patients is the most common complication associated with critical care. It has significant effects on physical and psychological health, mortality and quality of life. It is most severe in the first few days of illness and in the most critically unwell patients, with muscle loss estimated to occur at 2-3% per day. This muscle loss is likely a result of a reduction in protein synthesis relative to muscle breakdown, resulting in altered protein homeostasis. The associated weakness is associated with in an increase in both short- and long-term mortality and morbidity, with these detrimental effects demonstrated up to 5 years post discharge. This article highlights the significant impact that muscle wasting has on critically ill patients' outcomes, how this can be reduced, and how this might change in the future.
危重症患者的肌肉耗损是与重症监护最相关的常见并发症。它对身体和心理健康、死亡率和生活质量有重大影响。在疾病的最初几天和病情最危急的患者中最为严重，估计每天会损失 2-3%的肌肉。这种肌肉损失可能是由于蛋白质合成相对于肌肉分解减少所致，导致蛋白质平衡发生改变。相关的虚弱与短期和长期死亡率和发病率的增加有关，这些不利影响在出院后长达 5 年内都有体现。本文重点介绍了肌肉耗损对危重症患者预后的重大影响、如何减少这种影响，以及这种影响在未来可能会如何变化。
