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雌激素和孕激素对促性腺激素释放激素反应的调节作用位点。

Site of modulatory action of oestrogen and progesterone on gonadotrophin response to luteinizing hormone releasing factor.

作者信息

Fink G, Henderson S R

出版信息

J Endocrinol. 1977 Apr;73(1):165-70. doi: 10.1677/joe.0.0730165.

DOI:10.1677/joe.0.0730165
PMID:323392
Abstract

The effect of oestrogen and progesterone on the spontaneous release of gonadotrophins and on the gonadotrophin response to luteinizing hormone releasing factor has been examined in female rats subjected to hypothalamic deafferentation or pituitary stalk section. The results indicate that both steroids act at the level of the medial basal hypothalamus as well as the anterior pituitary gland; progesterone, for its full effect, also requires the integrity of connexions of the hypothalamus with other areas of the brain.

摘要

在接受下丘脑去传入神经支配或垂体柄切断术的雌性大鼠中,研究了雌激素和孕酮对促性腺激素自发释放以及对促性腺激素释放激素(LH-RH)反应的影响。结果表明,这两种类固醇激素在下丘脑内侧基底部以及垂体前叶水平均有作用;孕酮要发挥其全部作用,还需要下丘脑与脑其他区域连接的完整性。

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