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Gonadotrophin regulation in the lactating rat.

作者信息

Steger R W, Peluso J J

出版信息

Acta Endocrinol (Copenh). 1978 Aug;88(4):668-75. doi: 10.1530/acta.0.0880668.

DOI:10.1530/acta.0.0880668
PMID:356502
Abstract

Post-partum lactation in the rat is associated with follicular quiescence and an attenuation of gonadotrophin secretion. The present study demonstrates that the lactating rat responds to exogenous LH-releasing hormone (LH-RH) in a manner similar to dioestrous rats. Oestrogen priming increases the LH and FSH response to LH-RH to a smaller degree in ovariectomized, lactating, than in non-lactating, ovariectomized rats. Pituitary LH levels throughout lactation did not seem to be related LH-RH-induced LH release. A diminished post-castration rise in both LH and FSH, and a diminished positive feedback response to oestrogen administration were also observed and may indicate a disruption of gonadotrophin regulation at both the hypothalamic and the pituitary level.

摘要

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