Torres Vidal Alana, Medintz Igor L, Bui Hieu
Department of Electrical Engineering and Computer Science, The Catholic University of America, Washington, DC 20064, USA.
Center for Bio/Molecular Science and Engineering, Code 6900, U.S. Naval Research Laboratory, Washington, DC 20375, USA.
Micromachines (Basel). 2020 Apr 23;11(4):445. doi: 10.3390/mi11040445.
Researchers are continuously making progress towards diagnosis and treatment of numerous diseases. However, there are still major issues that are presenting many challenges for current medical diagnosis. On the other hand, DNA nanotechnology has evolved significantly over the last three decades and is highly interdisciplinary. With many potential technologies derived from the field, it is natural to begin exploring and incorporating its knowledge to develop DNA microsystems for biodiagnosis in order to help address current obstacles, such as disease detection and drug resistance. Here, current challenges in disease detection are presented along with standard methods for diagnosis. Then, a brief overview of DNA nanotechnology is introduced along with its main attractive features for constructing biodiagnostic microsystems. Lastly, suggested DNA-based microsystems are discussed through proof-of-concept demonstrations with improvement strategies for standard diagnostic approaches.
研究人员在多种疾病的诊断和治疗方面不断取得进展。然而，仍然存在一些重大问题，给当前的医学诊断带来了诸多挑战。另一方面，在过去三十年中，DNA纳米技术有了显著发展，且具有高度的跨学科性。由于该领域衍生出了许多潜在技术，自然而然地就开始探索并融入其知识，以开发用于生物诊断的DNA微系统，从而帮助解决当前的障碍，如疾病检测和耐药性问题。在此，介绍了疾病检测方面当前面临的挑战以及标准诊断方法。然后，简要概述了DNA纳米技术及其构建生物诊断微系统的主要吸引人的特性。最后，通过概念验证演示讨论了建议的基于DNA的微系统以及标准诊断方法的改进策略。
